| Player | School |
| James Russel | Cape Central |
| Trevor Blattner | Cape Central |
| John Mark Thomson | Cape Central |
| Whit Lynn | Cape Central |
| Arthur Pillsner | Cape Central |
| Eric Daume | Cape Central |
| Matt Litzenfelner | Jackson |
| Michael Schuette | Jackson |
| Matt Gordon | Jackson |
| Patrick Kohm | Jackson |
| Stuart Knowlan | Jackson |
| Balraj Dirnberger | Jackson |
| Matt Schinler | Poplar Bluff |
| Blake Collins | Poplar Bluff |
| Rudy Vance | Hillsboro |
| Ryan Menke | Hillsboro |
| James Shaner | Farmington |
| Michael Hall | Farmington |
2001 Boys Class 4A Southeast Region
Offensive Player of the Year
John Mark Thompson (Cape Central)
Defensive Player of the Year
Matt Litzenfelner (Jackson)
Goalkeeper
Trevor Blattner (Cape Central)
Coach of the Year
Tom Doyle (Cape Central)
